The components of poloxamer 188 solution pdf, 3 mb plasticizers brochure north america version. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol peg. Previous studies have shown that the erosion of poloxamer based gels, in aqueous media, is relatively fast and it also exhibits. Serasense sf 2 dimethicone cleanses oils away, whilst serasense cf cpm caprylyl methicone smoothes the eye area without tackiness. Pharmaceuticalgrade ingredients for the dermatology. Incorporating simvastatinpoloxamer 407 hydrogel into 3dprinted porous ti 6 al 4 v scaffolds for the promotion of angiogenesis, osseointegration and bone ingrowth view the table of contents for this issue, or go to the journal homepage for more home search collections journals about contact us. They are also used in topical dosage forms and rectal suppositories. In this study, we investigated the effects of poloxamer 407 as a carrier vehicle on rotator cuff healing at the repair site and compared it with those of a collagen sponge, which is a commonly used carrier vehicle. Through science and innovation we provide our customers with products to meet the current and future needs of business and society. Sigmaaldrich offers a number of poloxamer 188 products. Basf corporation evaluation of lutrol f grades prill vs.
Poloxamer 188 for the pharmaceutical industry, ludwigshafen, germany, 1997. The common available grades are poloxamer 68, 88, 98, 108, 124, 188, 237, 338, and 407. Poloxamer 188 p188 is a nonionic amphiphilic copolymer with hemorheologic, antithrombotic, antiinflammatory, and cytoprotective properties. Ibuprofen api dmfs us drug master file dmf details. Basf pharma ingredients and services offers our solutionsoriented skin delivery platform to formulators of otc and rx topical.
Ch 3 hoch 2ch 2o xch 2cho ych 2ch 2o xh lutrol f 68 nf important. Currently, excipientgrade poloxamer 188 nf, marketed by basf under the kolliphor p188 brand, is a polymer used in a variety of pharmaceutical and biological applications, such as a shear protectant in cell culture production. Basfs unparalleled portfolio of solubilizers and emulsifiers for topical products. Pharmaceuticalgrade ingredients for the dermatology industry.
Poloxamer 407 p407 and 188 p188 were obtained from basf co. The methods of determination are described in this monograph or in the general methods to be found in the european pharmacopoeia. The word poloxamer was coined by the inventor, irving schmolka, who received the patent for these materials in 1973. Assessment of transdermal penetration enhancement by topical. Poloxamer 407 about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Poloxamer 184 poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. They make this highlyefficient intermediate, used in many types of.
Data on pluronic polyols, basf wyandotte corporation, herein incorporated by reference. Basf corporation was supported on a polystyrene divinyl benzene solid matrix xad4. Information material on polyurethane products and systems. Besides clothing, spandex is being gradually applied in the medical and other industries. Poloxamerbased thermoreversible gel for topical delivery of. Safety assessment of poloxamers 101, 105, 108, 122, 123, 124, 181.
Pdf poloxamer hydrogels for biomedical applications. The degradation behavior of the poloxamer 407 hydrogel was observed and imaged every 3 days. Pdf poloxamers, poloxamines and polymeric micelles. Safety data sheet this sds summarises to our best knowledge at the date of issue, the chemical health and safety hazards of the material and general guidance on how to. Differential effects of commercialgrade and purified poloxamer. Process for producing a poloxamer gel download pdf. Publication of wo2009055312a1 publication critical patentwo2009055312a1en. Pluracare l 64 is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 2,900. The approximate lengths of the two peg blocks is 101 repeat units while the approximate length of the propylene. A nonionic surfactant that has general functionality of surfactant, emulsifier, solubilizer and stabilizer. Eur glycerol monostearate 4055 typ ii 30554444 50253254 50259522 uspnf.
March 6, 2020 finnish battery industry intensifies cooperation. The other reagents used in this grade were of analytical grade. Sep 18, 2014 register now and get a free online msds binder. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. List of drug master files dmf of poloxamer 182lf active pharmaceutical ingredient api submitted to the u. Used in toothpaste, whitening gels, mouthwash, sun and skin care applications. Physical and chemical properties as described by leaf 1967, many poloxamers dissolve in water and form gels when a concentrated aqueous solution is made. Determination of poloxamer 188 and poloxamer 407 using highperformance thinlayer chromatography in pharmaceutical formulations. Article information, pdf download for safety assessment of poloxamers 101, 105, 108. Despite their wide range of applications, limited analytical techniques have been reported in. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Poloxamers, available also under the trademark pluronics basf, are a class of watersoluble nonionic aba and bab triblock copolymers. Poloxamers and poloxamines are examples of biocompat.
Apr 11, 2014 poloxamer 188 p188 is a nonionic amphiphilic copolymer with hemorheologic, antithrombotic, antiinflammatory, and cytoprotective properties. Dual phase eye make up remover ec1 this dual phase formulation blends together to remove all eye make up, including waterproof. Information material on polyurethane systems and products. Basf pharmaceuticalgrade ingredients for the dermatology industry. Ph eur usp nf jp poloxamer 407 jpe polyoxyethylene 196. White to slightly yellowish waxy substance in the form of micropearls. Relevant identified uses of the substance or mixture and uses advised against identified uses laboratory reagent. Pdf this study investigates the potential of poloxamers as solid dispersions sds. Lutrol f 68 meets the requirements of the current uspnf family monograph, poloxamer. Poloxamer gels are conventionally prepared by either the hot process or the cold process. In the range of concentrations studied, the t solgel of the binary waterpoloxamer formulations was inversely proportional to the poloxamer concentration, with the appropriate t solgel value 32.
The influence of the composition and preparation method on the solgel transition temperature t solgel and rheological response of poloxamerbased formulations was determined. Currently, excipientgrade poloxamer 188 nf, marketed by basf under the kolliphor p188 brand, is a polymer used in a variety of. Information material on polyurethane systems and products basf. Poloxamer 105 benzoate is an ester of poloxamer 105 and benzoic acid and poloxamer 182 dibenzoate is the diester of poloxamer 182 and benzoic acid gottschalck and mcewen 2004. Technical information pluracare lf grades poloxamer. Humidity induced phase transformation of poloxamer 188 and its effect on physical stability of amorphous solid dispersion of amg 579, a pde10a inhibitor.
For protection from shear stress, poloxamer 188 has a long publication history as well as documented use in the manufacturing of approved biologics. Assessment of transdermal penetration enhancement by. Flexible excipient to overcome a wide range of pharmaceutical challenges that. It is a surfactant functioning both as cleansing and solubilizing agent. List of drug master files dmf of ibuprofen active pharmaceutical ingredient api submitted to the u. Pxm188 is an aba block type copolymer which contains around 80% poe units and 20% ppo units. Poloxamer 407 is a nonionic surfactant with the ability to increase the solubility of drugs e. The process involves premelting the poloxamer prior to mixing with cold water. With over 50 years experience in eopo chemistry, basf is committed to providing the poloxamer kolliphor p 188 bio, which is designed to meet your needs in quality, consistency, and performance. Incorporating simvastatin poloxamer 407 hydrogel into 3dprinted porous ti 6 al 4 v scaffolds for the promotion of angiogenesis, osseointegration and bone ingrowth view the table of contents for this issue, or go to the journal homepage for more home search collections journals about contact us my iopscience. Polythf for spandex and elastane basf intermediates. Emm 070801e00 january 2008 page 4 of 10 pluracare lf grades poloxamer applications it is suggested that these pluracare copolymers be considered for their general functionality as surfactants, emulsifiers, solubilizers and stabilizers in almost all. Table1 shows examples of commercially available pluronics. Pdf research for new therapies to treat diseases like cancer, it is one of the focus of health sciences.
Feb 15, 2018 for 40% poloxamer gels, the amount of drug permeated from the extruded gel was 2. Poloxamer complete drug information, side effects and. Our poloxamers are even compatible with challenging active ingredients such. Poloxamer 407 kolliphor p407 was kindly gifted by basf ludwigshafen, germany. C corresponding to the formulation containing 18% poloxamer 407. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb. First, the transparent poloxamer 407 hydrogel was stained with calcein for improved visualization. Since poloxamer 188 deliquesces at 40 c, 75% rh, it is plausible that the crystallization of 1 in the prototype tablets occurs through solubilization in the liquid poloxamer 188. Formulation development of a carrageenan based delivery.
Basf poloxamers offer better solubilizing properties compared to hpmc, pvp. Determination of poloxamer 188 and poloxamer 407 using. Determination of poloxamer 188 and poloxamer 407 using high. Learn about poloxamer from patients first hand experiences and trusted online health resources, including dosage, side effects and interactions. Fortum, basf, and nornickel sign cooperation agreement on battery recycling. Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj introduction lutrol f grades are block copolymers referred to as poloxamers, consisting of polyoxyethylene. The impurities of commercial grade poloxamer 188, as an example. Assessment of transdermal penetration enhancement by topical pharmaceutical excipients using skin pampa method m.
Poloxamer as an excipient authorstream presentation. Incorporating simvastatinpoloxamer 407 hydrogel into 3d. Despite their wide range of applications, limited analytical techniques have been reported in literature for characterizing poloxamers and few are. March 10, 2020 basf launches a new trimetal catalyst, developed in collaboration with and sponsored by sibanyestillwater and impala platinum. Apr 27, 2018 they are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. Wo2009055312a1 process for producing a poloxamer gel. Differential effects of commercialgrade and purified.
Poloxamers are also known by the trade names synperonics, pluronic, and kolliphor. Next, simvastatinpoloxamer 407 hydrogelpti scaffolds were constructed as described in section 2. Poloxamer selfassembly in aqueous solutions poloxamers are available in a broad range of molecular weights and ppopeo ratios. Effect of poloxamer 407 as a carrier vehicle on rotator cuff. This may explain the large variability seen in outcomes in research studies. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Possesses solubilizing, bodying and gelling properties. Effect of poloxamer on release of poorly water soluble drug. Basf to develop a high purity poloxamer for mast therapeutics. Humidity induced phase transformation of poloxamer 188 and. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers known as poloxamers. Basf is the first company in the world to offer triphenylphosphine tpp in the form of pellets. Thickening agent and gel former for the pharmaceutical industry.
Development of poloxamer gel formulations via hotmelt. Us drug master file basf maintains a drug master file for poloxamers at the fda and is familiar with supplying information to the fda to assist customers in obtaining fda authorizations. The advantage of spandex is its elasticity, making spandexcontaining clothes very comfortable to wear. At 40 c, 75% rh conditions, the poloxamer 188 in the tablet adsorbs 15% of water and deliquesces to form a liquid. They make this highlyefficient intermediate, used in many types of applications, significantly easier and safer to handle. Raw materialinci name % ww trade namesupplier function phase a. As the concentration of poloxamer in the gel increases, the amount of drug permeated from the formulation decreases as can be seen from figure 10. Poloxamer 188 pxm188 and poloxamer 407 pxm407 are among the most commonly used pxms. Technical datasheet supplied by basf poloxamer 407.
Basf report 2014 pdf download the entire basf report 2014 as a pdf. It potentially has clinical utility in diverse diseases, such as acute myocardial infarction, acute limb ischemia, shock, acute stroke, heart failure, and sickle cell crisis. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of. It is used as an emulsifier, solubilizer, dispersing and wetting agent in the preparation of solid dispersions, and for the enhancement of the bioavailability of.
You can find detailed information on our product range by looking up your industry or using our product finder. Loratadine, solid dispersions, poloxamer 188, poloxamer 407. Pdf dissolution rate enhancement and physicochemical. Download acrobat pdf file 207kb recommended articles citing articles 0.
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